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Wednesday, November 11, 2020 | History

3 edition of Follicular dendritic cells in normal and pathological conditions found in the catalog.

Follicular dendritic cells in normal and pathological conditions

Follicular dendritic cells in normal and pathological conditions

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  • 16 Currently reading

Published by R.G. Landes in Austin .
Written in English

  • Dendritic cells.,
  • Dendritic Cells -- physiology.,
  • Dendritic Cells -- pathology.

  • Edition Notes

    Includes bibliographical references and index.

    StatementErnst Heinen [editor].
    SeriesMolecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)
    ContributionsHeinen, E. 1947-
    LC ClassificationsQR185.8.D45 F65 1995
    The Physical Object
    Pagination[8] 184 p. :
    Number of Pages184
    ID Numbers
    Open LibraryOL788309M
    ISBN 100412101416
    LC Control Number95020664

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Follicular dendritic cells in normal and pathological conditions Download PDF EPUB FB2

Get this from a library. Follicular dendritic cells in normal and pathological conditions. [E Heinen;]. The pathogenesis of transmissible spongiform encephalopathies (TSEs) often includes a replication phase in lymphoid tissues before infection spreads to the central nervous system.

Recent studies show that the follicular dendritic cells of the germinal centres are critical for this replication. These cells are therefore potential targets for therapy or prophylaxis in natural TSEs, such as Cited by: Follicular dendritic cells in follicular lymphoma and types of non‐Hodgkin lymphoma show reduced expression of CD23, CD35 and CD54 but no association with clinical outcome Aims: Follicular dendritic cells (FDC) are specialized antigen‐presenting cells found exclusively in the germinal centre (GC), which can be detected in B cell non Cited by: FOLLICULAR DENDRITIC CELLS IN MAMMALS Monoclonal antibodies allowed us to study the network of FDCs in normal and pathological conditions (Lefevre at al., ).

Monoclonal antibodies stain FDC in the GC, mainly in the light zone of GC (Lefevre et al., ). To date,Author: Lucie Kratochvílová, Petr Sláma. Abstract. InNaiem et al., produced a murine monoclonal antibody recognizing tonsillar follicular dendritic cells (FDC). This anti-DRC 1 appeared highly selective for human FDC.

It has proved of great value in the analysis of the distribution of FDC in reactive lymphoid tissues, in follicular lymphomas and in other diseases, namely in : Nadine Antoine, Ernst Heinen, Alain Bosseloir, Catherine Beckers, Léon Simar.

In Primer to the Immune Response (Second Edition), iv) Follicular Dendritic Cells. Follicular dendritic cells (FDCs) have a dendritic morphology but are completely unrelated to DCs and pDCs in lineage and function. While DCs are critical for T cell responses, FDCs are important for B cell responses and are abundant in the secondary lymphoid organs where B cell activation occurs (see Ch.

Histologic sections showed lymph nodes with multi‐focal areas of atypical follicular dendritic cell (FDC) proliferation in intra‐follicular and inter‐follicular regions.

In one focus, these formed a mm expansile nodular mass with a storiform pattern of arrangement (Image 1 A). The aim of this study was to evaluate the pathological changes as well as the characterization of two antigen presenting cells, DC (CD1b, CD83 and MHC-II positive) and follicular dendritic cells (FDC) (CNA, S and CD83 positive) by immunohistochemistry in the hepatic lymph nodes (HLN) and livers of sheep during the early stages of.

expressed by synovial, vascular endothelial and follicular dendritic cells (16). Moreover, CD is also present on cells, in normal and pathological conditions (29). CDmediated signals are regulated at distinct levels: the first level concerns the ultrastructural organization of the.

Follicular dendritic cells (FDCs) are cells of the immune system found in primary and secondary lymph follicles of the B cell areas of the lymphoid tissue. [1] [2] [3] Unlike DCs, FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin.

Hailing Zhang, Robert W. Maitta, Pritish K. Bhattacharyya, Alina Dulau Florea, Filiz Sen, Qing Wang, Howard Ratech, γ-Synuclein Is a Promising New Marker for Staining Reactive Follicular Dendritic Cells, Follicular Dendritic Cell Sarcoma, Kaposi Sarcoma, and Benign and Malignant Vascular Tumors, The American Journal of Surgical Pathology,   Recent studies have indicated that the follicular dendritic cells (FDCs) of the germinal centres of the spleen, lymph nodes and Peyer’s patches are key players in pathogenesis.

The normal function of these cells is to trap and retain native antigen, in the form of immune complexes, for presentation to B cells 6. Association of PrP with FDCs. The Burkitt lymphoma cell line, L cells and the follicular lymphoma (FL) cell line, FLK‐1, require FDCs for their growth in vitro.

92, 93 Furthermore, L cells form tumours when inoculated with HK cells into nude mice. 84 In the absence of HK cells, L cells undergo apoptosis in vitro and do not form tumours in vivo.

The germinal centers play a key role in producing memory B cells and plasma cells. The main constituents of germinal center microenvironment are activated germinal-center B cells (centroblasts and centrocytes), follicular dendritic cells (FDCs), macrophages, CD4 + and CD8 + T cells, and dendritic cells (6, 10, 12, 13, 16, 17, 26).FDCs belong to so-called B-cell-associated dendritic cells with.

1. Introduction. Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm whose cells show phenotypic features of normal FDCs. Since first description inonly a few case series have been published on this entity.Follicular dendritic cell sarcoma has been well known for being mistaken for a variety of neoplasms (mainly meningioma), particularly at extranodal sites.

INTRODUCTION. Dendritic cells (DCs) comprise a group of large, nonlymphocytic, class II major histocompatibility complex‐positive mononuclear cells that are crucial in the presentation of antigen during the elicitation of primary immune responses against pathogens and tumors.

They originate from hematopoietic precursors in the bone marrow and subsequently migrate to peripheral tissues. Follicular Dendritic Cells: B-Cell Proliferation and Maturation1 Andras K. Szakal2 and John G. Tew with a variety of pathological conditions and may be important in promoting the disease.

For example, FDC clusters are of young or old FDC did produce a normal anamnestic re sponse in old mice. These results suggested that functional. Follicular dendritic cells display microvesicle-associated LMP1 in reactive germinal centers of EBV+ classic Hodgkin lymphoma Stefania Uccini, 1 Mazin F.

Al-Jadiry, 2 Giuseppina Pepe, 3 Anna Pasquini, 3 Adel R. Alsaadawi, 4 Salma A. Al-Hadad, 2 Arianna Di Napoli, 3 Claudio Tripodo, 5, 6 and Luigi Ruco 3. INTRODUCTION. Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor derived from hyperplasia dendritic cells.

FDCS cases were first reported and discussed by Monda et al[] in Unlike normal dendritic cells, follicular dendritic cells have no ability to present antigens[].FDCS, derived from hyperplastic dendritic cells, usually occurs in lymph nodes, especially.

Tissues affected by chronic lymphoproliferative inflammation display variable numbers of T and B lymphocytes, along with plasma cells, macrophages, dendritic cells (DCs), and FDCs. All these inflammatory cells may frequently evolve into newly formed follicles similar to those found in secondary lymphoid organs, thus giving rise to a.

1 Introduction. Follicular dendritic cell sarcoma (FDCS), also known as dendritic cell sarcoma with unclear pathogenesis, is a relatively rare malignant tumor originating from follicular dendritic cells (FDC) at both nodal and extra-nodal sites FDC. FDC are located in the germinal centers of primary and secondary lymphoid follicles and play an important role in antigen presentation to B cells.

Sepsis is the leading cause of death for critically ill patients in recent years. Dendritic cells (DCs) are important antigen-presenting cells and play a key role in immune response by regulating the innate and adaptive immunity.

The number of DCs, the differentiation of monocytes into DCs, and the levels of surface molecules associated with the function of DCs are changed in the development.

Get this from a library. Dendritic Cells in Fundamental and Clinical Immunology. [Eduard W A Kamperdijk; Paul Nieuwenhuis; Elisabeth C M Hoefsmit] -- These Proceedings contain the contributions of the participants of the Second International Symposium on Dendritic Cells that was held from the 1st to 25th of June in Amsterdam, the Netherlands.

Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. Lymph nodes contain nonlymphoid accessory cells including follicular dendritic cells.

HIV-1 disease, can slowly reverse pathological changes in the FDC network. Lymphoid follicles are the site where B cell clones with high affinity for specific antigens are selected to generate the humoral immune response.

Follicular dendritic cells (FDCs) that trap and retain antigens play a. Ohgami, RS, Zhao, S, Ohgami, JK, et al. TdT+ T-lymphoblastic populations are increased in Castleman disease, in Castleman disease in association with follicular dendritic cell tumors, and in angioimmunoblastic T-cell lymphoma.

Am J Surg Pathol; 36 (): –   Follicular dendritic cell sarcoma (FDCS) is a rare mesenchymal tumor that mostly occurs in systemic lymph nodes. FDCS in the uterine cervix has not yet been reported. A year-old woman was referred to our department with a cervical tumor, which was histologically suspected to be undifferentiated carcinoma.

She underwent hysterectomy, salpingo-oophorectomy, and pelvic. (centroblasts and centrocytes), follicular dendritic cells (FDCs), macrophages, CD41 and CD81 T cells, and dendritic cells (6, 10, 12, 13, 16, 17, 26). FDCs belong to so-called B-cell-associ-ated dendritic cells with desmosomal junctions (29), and they.

Follicular dendritic cell sarcoma (FDCS) is a spindle cell neoplasm of histiocytic-dendritic cells origin. It is known to occur in lymph nodes and rarely has been reported in extranodal tissues.

Mature B cells that resemble follicular B cells in spleen can be identified in peritoneal cavity (where they are referred to as B2), in bone marrow (where they may represent cells recirculating in blood that contaminate bone marrow cell preparations), and in lymph nodes (Figure 4 (A)).

An analysis of the distance between follicular-like/B2 B cells in different tissues using MDS, comparing bone. Introduction. Follicular dendritic cell sarcoma (FDCS) is a rare type of tumor, since the first description of the disease by Monda, etc.

in [].Until now a total of about cases has been reported worldwide, FDCS is still extremely rare tumor and often misdiagnosed [].Throughout the relevant literature, we found that the malignant degree of all patients diagnosed with malignant tumors.

These cells have clear cytoplasm and clear cytoplasmic border. The tumor cells may be admixed with other cells, such as small lymphocytes, plasma cells, eosinophils, and histiocytes.

There is also an increase in high endothelial venules (HEVs). In addition, proliferation of follicular dendritic cells (CD21 +), typically surrounding HEVs, is. The molecular profile of AITLs was characterized by a strong microenvironment imprint (overexpression of B-cell- and follicular dendritic cell-related genes, chemokines, and genes related to.

Over the course of HIV-1 infection, the lymphoid follicles where the humoral immune response is generated initially increase in size and number and then progressively involute. In advanced disease, the network of the processes of follicular dendritic cells (FDCs) that serve as antigen repositories and anatomical substrate for B and T cells and antigen to interact is destroyed, contributing to.

However, the identification of CXCL13+ cells remains unclear in terms of whether they are neoplastic cells (or TFH cells) or follicular dendritic cells (FDCs) in both AITL and normal germinal centers.

Follicular dendritic cell sarcoma: two rare case series and a brief review of the literature Yuan Ma,1,* Jujie Sun,2,* Cuicui Yang,1 Dandan Yuan,3 Jie Liu3 1Department of Oncology, Shandong Cancer Hospital & Institute, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong Province, People’s Republic of China; 2Department of Pathology.

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune main function is to process antigen material and present it on the cell surface to the T cells of the immune system.

They act as messengers between the innate and the adaptive immune systems. Dendritic cells are present in those tissues that are in contact with the external. In some reactive conditions, a rim of B cells with slightly more cytoplasm accumulates outside of the mantle zone; cells occupying this region are called marginal zone B cells.

[7], [8] Both the primary and secondary follicles are rich in follicular dendritic cells. Follicular dendritic cell sarcoma is a rare malignancy arising from follicular dendritic cells, which form a meshwork within lymphoid follicles.

Traditional treatment of metastatic disease with CHOP chemotherapy, the most commonly used regimen for lymphoid malignancies, has met with limited success. I report herein two cases of follicular dendritic cell sarcoma metastatic to the liver treated.

Follicular dendritic cells are antigen-presenting cells for B cells and have a synthesis or secretion function for some substances such as cytokines (Park et al.

,), suggesting the role of RCN in secretion function. Despite high proliferating activity of lymphocytes in germinal centers, they are entirely negative for RCN. CD35 (a marker of follicular dendritic cells) are positive. Although CD10 is infrequently positive in follicular lymphoma, the morphology, immunohistochemistry, the presence of plasmacytoid cells and lymphoepithelial lesions are in favor of MALT lymphoma rather than folli-cular lymphoma.

The present tumor is not mantle cell. Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of IL1RN in papillary thyroid carcinoma (PTC) remains undetermined.

We obtained IL1RN expression data from The Cancer Genome Atlas (TCGA) database. Enrichment analysis of coexpressed genes and IL1RN methylation analysis were performed via .The CXCL13 (CXC Ligand 13) protein, also known as B cell attracting chemokine 1 (BCA-1) or B lymphocyte chemo-attractant (BLC) is a chemokine ligand.

It is expressed in secondary lymphoid tissue by stromal cells within B-cell follicles and by follicular dendritic cells, macrophages, and germinal center T cells. The CXCL13 receptor CXCR5 is expressed on follicular B cells.